Ramona Quimby

Deniz Pelin Pruitt (cast A) / Jacqueline Mazique (cast 1)
 
Beezus Quimby

Kayla Griffith (cast 1) / Anna Meehan (cast A)
 
Dorothy Quimby

Lilliann Vigil
 
Bob Quimby

(TBA)
 
Aunt Bea

Moriah Pierre-Louis (cast A) / Laura LaChapelle (Cast 1)
 
Howie

Alexander Jon DeYoung (cast A) / Benjamin DeYoung (cast 1)
 
Uncle Hobart

(TBA)
 
Susan

Karin Johnson (cast A) / Sydni Norman (cast 1)
 
Mrs. Kemp

Catherine Hundt
 
Mrs. Griggs

Carly Mayer
                    
Selma & Doctor

Arielle Mason
 
Tammy/Director

Katy Goff
 
Old Man/Mr. Frost

(TBA)
 
Various Roles

Jordan Hurley, Jazmine Mazique, Nicole Wood, Sarah Esparza, Shekinah Lee, Skilah Arnold, Rae Katherine Sweet, Esther Lagerwey, Rain Perez
 
Kids

Aashante Chapman, Chase Gray, Amber Haywood, LaTonia Cohn, Charlee'ette Glover, Kayla Hurley, Faith Martin, Tyler Burnett,

Kyle Johnson, Robert Lee, Carrington Johnson, Vernell Johnson